MAPK8
mitogen-activated protein kinase 8
Sinonimi:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Specie:
Human MAPK8 (5599), Mouse Mapk8 (26419), Rat Mapk8 (116554), chicken MAPK8 (423778), cow MAPK8 (539941), Goat MAPK8 (100861087), domestic cat MAPK8 (101091310), Horse MAPK8 (100051798), dog MAPK8 (477746), Domestic Rabbit MAPK8 (100346929) ...Più
ID UniProtKB:
ID gene:
- Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
- Mouse(26419) mitogen-activated protein kinase 8
- Rat(116554) mitogen-activated protein kinase 8
- chicken(423778) mitogen-activated protein kinase 8
- cow(539941) mitogen-activated protein kinase 8
- Goat(100861087) mitogen-activated protein kinase 8
- domestic cat(101091310) mitogen-activated protein kinase 8
- Horse(100051798) mitogen-activated protein kinase 8
- dog(477746) mitogen-activated protein kinase 8
- Domestic Rabbit(100346929) mitogen-activated protein kinase 8
- sheep(101116201) mitogen-activated protein kinase 8
- domestic guinea pig(100722333) mitogen-activated protein kinase 8
- naked mole-rat(101715259) mitogen-activated protein kinase 8
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ELISA
N° Catalogo
Descrizione
Specie
Cell-Based ELISA for detecting phospho-JNK (pThr183 / pTyr185) in cultured cell lines, 96 assays,
Specie
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Specie
rat, human, mouse
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, rat
Applicazione
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody, from rabbit, purified by affinity chromatography,
Reattività con
xenopus, bovine, canine, chicken, equine, horse, human, mouse, rat
Applicazione
activity assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho JNK (Thr183, Tyr185) Antibody, clone 3F7, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse
Applicazione
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
PhosphoDetect Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
Reattività con
caenorhabditis elegans, drosophila, chicken, human, mouse, rat
Applicazione
Anti-JNK1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Small Molecule - Inhibitor
Proteins
N° Catalogo
Descrizione
Specie
JNK1α1/SAPK1c Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays.,
Specie
human
JNK1α1/SAPK1c Protein, active, 10 µg, Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.,
Specie
human
JNK1, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
mouse