- A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation.
A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation.
Current Alzheimer research (2015-05-06)
Sharon Lai-Fung Chan, Lihua Lu, Tsz Lung Lam, Siu-Cheong Yan, Chung-Hang Leung, Dik-Lung Ma
PMID25938869
RÉSUMÉ
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
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Chlorure de sodium, for molecular biology, DNase, RNase, and protease, none detected, ≥99% (titration)
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Chlorure de sodium solution, 5 M in H2O, BioReagent, for molecular biology, suitable for cell culture
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Chlorure de sodium, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%