Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Macromolecular bioscience (2014-10-22)

Michelle A Ouimet, Renata Fogaça, Sabrina S Snyder, Sameer Sathaye, Luiz H Catalani, Darrin J Pochan, Kathryn E Uhrich

RÉSUMÉ

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.

MATÉRIAUX

Référence du produit

Marque

Description du produit

D2650

Sigma-Aldrich

Diméthylsulfoxyde, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

34865

Sigma-Aldrich

Tetrahydrofurane, inhibitor-free, suitable for HPLC, ≥99.9%

472301

Sigma-Aldrich

Diméthylsulfoxyde, ACS reagent, ≥99.9%

D8418

Sigma-Aldrich

Diméthylsulfoxyde, for molecular biology

34856

Sigma-Aldrich

Dichlorométhane, suitable for HPLC, ≥99.8%, contains amylene as stabilizer

34869

Sigma-Aldrich

Diméthylsulfoxyde, suitable for HPLC, ≥99.7%

D65100

Sigma-Aldrich

Dichlorométhane, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

D2438

Sigma-Aldrich

Diméthylsulfoxyde, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

C2432

Sigma-Aldrich

Chloroforme, contains 100-200 ppm amylenes as stabilizer, ≥99.5%

360589

Sigma-Aldrich

Tetrahydrofurane, contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%

D5879

Sigma-Aldrich

Diméthylsulfoxyde, ReagentPlus^®, ≥99.5%

360570

Sigma-Aldrich

Pyridine, ACS reagent, ≥99.0%

650498

Sigma-Aldrich

Chloroforme, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains amylenes as stabilizer

650463

Sigma-Aldrich

Dichlorométhane, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains 50-150 ppm amylene as stabilizer

366927

Sigma-Aldrich

Chloroforme, suitable for HPLC, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer

D4540

Sigma-Aldrich

Diméthylsulfoxyde, ≥99.5% (GC), suitable for plant cell culture

319988

Sigma-Aldrich

Chloroforme, contains ethanol as stabilizer, ACS reagent, ≥99.8%

401757

Sigma-Aldrich

Tetrahydrofurane, anhydrous, ≥99.9%, inhibitor-free

276855

Sigma-Aldrich

Diméthylsulfoxyde, anhydrous, ≥99.9%

41640

Sigma-Aldrich

Diméthylsulfoxyde, puriss. p.a., ACS reagent, ≥99.9% (GC)

270997

Sigma-Aldrich

Dichlorométhane, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

270407

Sigma-Aldrich

Pyridine, suitable for HPLC, ≥99.9%

G8540

Sigma-Aldrich

L-Glutamine, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source

186562

Sigma-Aldrich

Tetrahydrofurane, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

320269

Sigma-Aldrich

Dichlorométhane, ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

471283

Sigma-Aldrich

Triéthylamine, ≥99.5%

G3126

Sigma-Aldrich

L-Glutamine

34854

Sigma-Aldrich

Chloroforme, suitable for HPLC, ≥99.8%, amylene stabilized

32222

Sigma-Aldrich

Dichlorométhane, puriss. p.a., ACS reagent, reag. ISO, ≥99.9% (GC)

P57506

Sigma-Aldrich

Pyridine, ReagentPlus^®, ≥99%