Accéder au contenu
Merck
  • 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.

Bioorganic & medicinal chemistry letters (2006-06-30)
Jill Wood, Cedo M Bagi, Christiana Akuche, Antonietta Bacchiocchi, Jeremy Baryza, Marie-Luise Blue, Catherine Brennan, Ann-Marie Campbell, Soongyu Choi, James H Cook, Patricia Conrad, Brian R Dixon, Paul P Ehrlich, Todd Gane, David Gunn, Ted Joe, Jeffrey S Johnson, Jerold Jordan, Richard Kramss, Peiying Liu, Joan Levy, Derek B Lowe, Ian McAlexander, Reina Natero, Anikó M Redman, William J Scott, Christopher Town, Ming Wang, Yamin Wang, Zhonghua Zhang
RÉSUMÉ

A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17beta-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.

MATÉRIAUX
Référence du produit
Marque
Description du produit

Sigma-Aldrich
Phenylpropiolic acid, 99%