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  • Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Journal of controlled release : official journal of the Controlled Release Society (2010-07-21)
Janine Jansen, Mark J Boerakker, Jean Heuts, Jan Feijen, Dirk W Grijpma
RÉSUMÉ

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

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Sigma-Aldrich
1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, ≥99%
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Sigma-Aldrich
Vinyl acetate, contains 3-20 ppm hydroquinone as inhibitor, ≥99%
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Supelco
Vinyl acetate, analytical standard
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Supelco
Vinyl acetate solution, certified reference material, 5000 μg/mL in acetonitrile
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Sigma-Aldrich
mono-Ethyl fumarate, 95%
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Vinyl acetate, European Pharmacopoeia (EP) Reference Standard
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