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T8806

Sigma-Aldrich

Thymopentin

≥97% (HPLC)

Synonyme(s) :

TP5, Arg-Lys-Asp-Val-Tyr

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About This Item

Formule empirique (notation de Hill):
C30H49N9O9
Numéro CAS:
69558-55-0
Poids moléculaire :
679.76
Numéro MDL:
MFCD00214200
Code UNSPSC :
12352209
ID de substance PubChem :
329826886
Nomenclature NACRES :
NA.26

product name

Thymopentin, ≥97% (HPLC)

Niveau de qualité

200

Pureté

≥97% (HPLC)

Forme

powder

Couleur

white

Application(s)

cell analysis

Température de stockage

−20°C

Chaîne SMILES 

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1

Clé InChI

PSWFFKRAVBDQEG-YGQNSOCVSA-N

Amino Acid Sequence

Arg-Lys-Asp-Val-Tyr

Description générale

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).

Actions biochimiques/physiologiques

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Antonia Patruno et al.
Nitric oxide : biology and chemistry, 27(3), 143-149 (2012-06-23)
While thymopentin has been used for many years in the experimental treatment of Sézary syndrome (SS), a rare and very aggressive lymphoma, its mechanism of action is still not known. Herein we show that this peptide acts as an inhibitor
Wendy B London et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(24), 3286-3292 (2011-07-20)
Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in selection of optimal therapy. Our aim was to determine which factors were significantly predictive of postrelapse overall survival (OS)
Bo Yang et al.
Hematological oncology, 30(3), 115-122 (2012-09-14)
The elderly population is susceptible to haematological malignancies, and these elderly patients are intolerant to cytotoxic drugs. Therefore, the exploration of a safe and reliable strategy exclusive of chemotherapy is critical in improving the prognosis of elderly patients with haematological
J Duchateau et al.
Medical oncology and tumor pharmacotherapy, 6(1), 19-23 (1989-01-01)
Immunomodulation is interpreted as a temporary alert in a certain part of the immune system. The activation of immune competent cells is presented as a possible basic mechanism of this phenomenon. In the absence of a primary stimulus, immunomodulation remains
G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
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