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T5662

Sigma-Aldrich

Toxic shock syndrome toxin-1 from Staphylococcus aureus

Synonyme(s) :

Staphylococcal Enterotoxin F, TSST-1

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About This Item

Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Composition

Contains ~50% protein (Lowry); balance primarily sodium chloride and sodium phosphate buffer.

Niveau de qualité

Disponibilité

not available in USA

Solubilité

H2O: soluble 0.50-0.60 mg/mL, clear to slightly hazy, colorless to faintly yellow

Température de stockage

−20°C

Application

TSST-1 has been used for superantigen stimulation in T cells. Furthermore, studies have reported that TSST-1 can induce TNF-α secretion in peripheral blood mononuclear cells (PBMCs)4,5.

Actions biochimiques/physiologiques

Superantigen for T-lymphocytes.

Notes préparatoires

Toxic shock syndrome toxin-1 (TSST-1) is soluble in water at 0.50 - 0.60 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Pictogrammes

Skull and crossbones

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

L Blanco et al.
Infection and immunity, 58(9), 3020-3028 (1990-09-01)
Toxic shock syndrome toxin 1 (TSST-1), a 22-kilodalton protein made by strains of Staphylococcus aureus harboring the chromosomal toxin gene, may elicit toxic shock syndrome in humans. In vitro, TSST-1 induces T cells to proliferate and macrophages to secrete interleukin-1.
M Ramírez et al.
International immunology, 11(9), 1479-1489 (1999-08-28)
The superantigen toxic shock syndrome toxin (TSST)-1 can induce tumor necrosis factor (TNF)-alpha expression in T cells and monocytes, through different signaling pathways. We have stimulated peripheral blood mononuclear cells with TSST-1 and found that the major cell producers of
M Buxadé et al.
Immunology, 102(4), 416-425 (2001-05-01)
Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine produced by several cell types, including T cells upon antigen stimulation. Its production is crucial for the development of an early defence against many pathogens, but its beneficial effects are dependent on
Khojasteh V Javid et al.
Iranian journal of microbiology, 3(4), 170-176 (2012-04-25)
The aim of study was to develop a rapid assay, dye labelled monoclonal antibody assay (DLMAA), using non-radioactive organic synthetic dyes for identification of Toxic Shock Syndrome Toxin-1 (TSST-1) producing strains of Staphylococcus aureus. The assay protocol required only two
Microbial "superantigens".
M L Misfeldt
Infection and immunity, 58(8), 2409-2413 (1990-08-01)

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