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Principaux documents

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T2000

Sigma-Aldrich

Testosterone β-D-glucuronide

Synonyme(s) :

17β-Hydroxy-4-androsten-3-one 17-D-glucuronide, 4-Androsten-17β-ol-3-one 17-glucuronide

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About This Item

Formule empirique (notation de Hill) :
C25H36O8
Numéro CAS:
1180-25-2
Poids moléculaire :
464.55
Numéro MDL:
MFCD00056482
Code UNSPSC :
12352200
ID de substance PubChem :
24900003

Contrôle du médicament

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

Chaîne SMILES 

CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O

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Application

Testosterone has been used as a substrate for UDP-glucuronyltransferase based drug metabolism assays using microsome-encapsulation techniques.

Actions biochimiques/physiologiques

Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it appears to mediate several biological functions.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
069F3799

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L Dehennin
The Journal of endocrinology, 142(2), 353-360 (1994-08-01)
Testosterone administration to male athletes can be safely detected in the vast majority of cases by the urinary excretion ratio of testosterone to epitestosterone glucuronides (TG/EG), which may not exceed 6. Some rare cases of physiologically high TG/EG ratios (between
Taina Sten et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(2), 417-423 (2008-11-22)
Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17. Testosterone is the predominant male sex hormone, whereas the role of epitestosterone is largely unclear. In humans, both androgens are excreted mainly as
D E Kime et al.
Ecotoxicology and environmental safety, 34(2), 165-173 (1996-07-01)
Testicular and ovarian fragments of Carassius auratus, taken during the reproductively active prespawning phase (June) of its annual reproductive cycle, were incubated with different concentrations (0 mg/ml, 0 ppm; 0.001 mg/ml, 1 ppm; 0.01 mg/ml, 10 ppm; and 0.02 mg/ml
S Ikushiro et al.
Biochemistry, 36(23), 7154-7161 (1997-06-10)
The interactions between UDP-glucuronosyltransferase (UGT) isozymes, UGT1s and UGT2B1, in rat hepatic microsomes were investigated using an immunopurification technique with anti-peptide antibodies and a chemical cross-linking strategy. A 50 kDa protein coimmunopurified with UGT1s was identified as UGT2B1 by amino-terminal
Serena Ambrosini et al.
The Analyst, 137(1), 249-254 (2011-10-29)
Two molecularly imprinted polymers (MIPs) that we recently described to be class-selective for glucuronides have been successfully exploited for the molecularly imprinted solid-phase extraction (MISPE) of testosterone glucuronide (TG) from its parent drug (T) in urine. Both sorbents targeted the
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