SRP6297
Cathepsin S human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonyme(s) :
CTSS
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in HEK 293 cells
Pureté
≥95% (SDS-PAGE)
Forme
liquid
Poids mol.
~37 kDa
Conditionnement
pkg of 10 μg
pkg of 50 μg
Concentration
0.2 μM
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... CTSS(1520)
Description générale
Cathepsin S (CTSS) is a lysosomal cysteine endopeptidase of the papain family or C1 family. It is produced as an inactive preproenzyme which is then converted into the active form in lysosomes and late endosomes.
Actions biochimiques/physiologiques
Cathepsin S (CTSS) is a key participant in MHC (major histocompatibility complex) class II-mediated immune responses, where CTSS degrades Ii (type II membrane glycoprotein invariant chain) sequence of MHC II aβ heterodimers. Ii contains signaling motifs and its degradation leads to successful association of class II associated invariant chain peptide (CLIP) with the peptide groove of the MHC class II molecule. This is essential for antigen loading on MHC II complex during antigen presentation. Overexpression of this protein in mice leads to increased proteinase-activated receptor-2 (PAR-2) expression in dendritic cells resulting in scratching behavior and Th1 (T-helper) cell-associated cytokine expression. This can eventually lead to chronic atopic dermatitis in mice.
Forme physique
A 0.2 μM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Sarah F Hamm-Alvarez et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1872-1881 (2014-03-20)
The diagnosis of Sjögren's syndrome (SS) in routine practice is largely a clinical one and requires a high index of suspicion by the treating physician. This great dependence on clinical judgment frequently leads to delayed diagnosis or misdiagnosis. Tear protein
Nari Kim et al.
The Journal of investigative dermatology, 132(4), 1169-1176 (2011-12-16)
Atopic dermatitis (AD) is a chronically relapsing, non contagious pruritic skin disease with two phases: acute and chronic. Cysteine protease cathepsin S (CTSS) is involved in inflammatory processes, possibly leading to atherosclerosis and asthma. Recently, it has been reported that
Si-Tu Xue et al.
RSC advances, 9(15), 8600-8607 (2019-03-14)
Cathepsin K (Cat K) is a predominant cysteine protease and highly potent collagenase expressed in osteoclasts. Cat K inhibitors are anti-resorptive agents to treat osteoporosis. A novel scaffold of cathepsin K inhibitors, exemplified by lead compound 1x, was used as
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique