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Principaux documents

COO/COA

SRP6251

CCL6 from mouse

Name: CCL6 from mouse
Brand: SIGMA

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonyme(s) :

C10, CCL6, MRP-1, SCYA6

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About This Item

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.32

Source biologique

mouse

Produit recombinant

expressed in HEK 293 cells

Étiquette/Marqueur

6-His tagged (C-terminus)

Essai

≥95% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

calculated mol wt 11.4 kDa (The predicted N-terminus is Gly22.)
observed mol wt 14 kDa by SDS-PAGE (reducing)

Conditionnement

pkg of 10 μg

Impuretés

<1 EU/μg endotoxin (LAL test)

Numéro d'accès UniProt

P27784

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... CCL6(20305)

Description générale

Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. CCL6 has only been identified in rodents. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where it is strongly induced upon GM-CSF stimulation. Mouse CCL6 expression was also shown to be strongly induced by interleukin-4 (IL-4) in mouse macrophages and by cytokine IL-13 in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.

Forme physique

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.

Ma B

Journal of Immunology (2004)

The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines.

Berger MS

Dna and Cell Biology (1993)

Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes.

Orlofsky A

Cell Regulation (1991)

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