SRP5166
BAX, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
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About This Item
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Description générale
BCL2 associated X, apoptosis regulator (BAX) is a proapoptotic protein of the B-cell lymphoma 2 (BCL2) protein family. The gene encoding it is localized on human chromosome 19q13.33.
Actions biochimiques/physiologiques
BCL2 associated X, apoptosis regulator (BAX) forms a heterodimer with B-cell lymphoma 2 (BCL2) and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c. The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Forme physique
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Notes préparatoires
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Role of Bcl-2 family proteins in apoptosis:
apoptosomes or mitochondria?
apoptosomes or mitochondria?
Yoshihide Tsujimoto
Genes Cells (2001)
Bcl-2 family proteins and cancer
KW Yip
Oncogene (2008)
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
P. N. Kelly
Cell Death and Differentiation (2011)
Wnt signal transduction pathway and apoptosis: a review
Nives P
Cancer Cell International (2010)
S Shimizu et al.
Nature, 399(6735), 483-487 (1999-06-12)
During transduction of an apoptotic (death) signal into the cell, there is an alteration in the permeability of the membranes of the cell's mitochondria, which causes the translocation of the apoptogenic protein cytochrome c into the cytoplasm, which in turn
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