SRP4247

MIP-1beta human

recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)

• Synonyme(s) : CCL4, MIP-1- β, Macrophage inflammatory protein 1-β, Small inducible cytokine A4, T-cell activation protein 2
• Numéro MDL: MFCD00213005
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Essai: ≥99% (HPLC); ≥99% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~7.6 kDa
• Conditionnement: pkg of 10 μg
• Impuretés: endotoxin, tested
• Numéro d'accès NCBI: P13236
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... CCL4(388372)

Description

Description générale

MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), is a CC chemokine gene localized to human chromosome 17q12. It is a copy number variable gene which shares 95% sequence homology with its non-copy number variable paralogues CCL4. MIP-1β is expressed by a wide range of cells including immune cells, such as monocytes, B and T cells, fibroblasts, endothelial, and epithelial cells.

Actions biochimiques/physiologiques

MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), interacts with its major G protein-coupled receptors CCR5 and CCR8, and promotes the migration of immune cells, such as monocytes, natural killer (NK) cells, and T cells, maturation of dendritic cells (DCs), T cell and granulocyte activation, and T cell differentiation. It is an age associated inflammatory cytokine, and it shows elevated expression in the monocytes and blood of elderly individuals. MIP-1β plays a wide role in immune responses, and hence, its expression is tightly controlled during T-cell differentiation and activation.

Forme physique

Lyophilized without any additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.