SML0407

ML 141

≥98% (HPLC)

• Synonyme(s) : 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
• Formule empirique (notation de Hill): C₂₂H₂₁N₃O₃S
• Numéro CAS: 71203-35-5
• Poids moléculaire : 407.49
• Numéro MDL: MFCD05987165
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825402
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL (warmed, clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O
• InChI: 1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
• Clé InChI: QBNZBMVRFYREHK-UHFFFAOYSA-N

Description

Application

ML 141 has been used:

• to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
• as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
• as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
• as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Actions biochimiques/physiologiques

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC₅₀ for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable