SBR00038

Hygromycin B

Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

• Formule empirique (notation de Hill): C₂₀H₃₇N₃O₁₃
• Numéro CAS: 31282-04-9
• Poids moléculaire : 527.52
• Code UNSPSC : 51281624
• Nomenclature NACRES : NA.76

Propriétés

• Nom du produit: Hygromycin B, Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus
• Source biologique: Streptomyces hygroscopicus
• Niveau de qualité: 200
• Forme: solid
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; fungi; viruses
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: N([C@@H]1[C@H]([C@@H]([C@H]([C@@H](C1)N)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]3O[C@@]4(O[C@@H]32)O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)[C@H](N)CO)O)CO)O)C
• InChI: 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
• Clé InChI: GRRNUXAQVGOGFE-XKIAHZFYSA-N

Description

Description générale

Chemical structure: aminoglycoside

Application

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

Actions biochimiques/physiologiques

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H310 + H330
• Conseils de prudence: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classification des risques: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable