SAB6010057

Anti-phospho-ERN1 (S724) antibody, clone 1F12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonyme(s) : Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1
• Code UNSPSC : 12352203

Propriétés

• Produit recombinant: expressed in HEK 293 F cells
• Niveau de qualité: 100
• Conjugué: unconjugated
• Type de produit anticorps: primary antibodies
• Clone: 1F12, recombinant monoclonal
• Forme: liquid
• Poids mol.: 150 kDa
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Concentration: 0.6mg/ml
• Technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• Isotype: IgG
• Numéro d'accès UniProt: O75460
• Conditions d'expédition: wet ice
• Température de stockage: -10 to -25°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer724)

Description

Description générale

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

Immunogène

A synthesized peptide derived from human Phospho-ERN1 (S724)

Séquence

GRH-pS-FSR

Forme physique

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stockage et stabilité

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable