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SAB5200035

Sigma-Aldrich

Monoclonal Anti-HCN4 antibody produced in mouse

clone S114-10, 1 mg/mL, purified immunoglobulin

Synonyme(s) :

Anti-HCN4, S141-10, Anti-hyperpolarization activated cyclic nucleotide gated potassium channel 4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

S114-10, monoclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen predicted mol wt 130 kDa

Espèces réactives

rat, human, mouse

Concentration

1 mg/mL

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... HCN4(59266)

Catégories apparentées

Description générale

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel. HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.

Spécificité

Detects ~130 kDa. No cross-reactivity against other HCNs

Immunogène

Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Hughes DI
Neuroscience (2013)
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Zhang Q
Biochimica et Biophysica Acta (2009)
Dandan Liang et al.
Protein & cell, 12(7), 545-556 (2021-02-07)
Activation of the heart normally begins in the sinoatrial node (SAN). Electrical impulses spontaneously released by SAN pacemaker cells (SANPCs) trigger the contraction of the heart. However, the cellular nature of SANPCs remains controversial. Here, we report that SANPCs exhibit
NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochemical and Biophysical Research Communications (2007)
Victor Naumov et al.
Journal of neurophysiology, 121(6), 2126-2139 (2019-04-04)
The inferior colliculus (IC) is a large midbrain nucleus that integrates inputs from many auditory brainstem and cortical structures. Despite its prominent role in auditory processing, the various cell types and their connections within the IC are not well characterized.

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