SAB4702139

Monoclonal Anti-CD1a PE produced in mouse

• Synonyme(s) : FCB6, HTA1, Leu-6, T6
• Code UNSPSC : 12352203

Propriétés

• Conjugué: phycoerythrin (R-PE) conjugate
• Niveau de qualité: 100
• Type de produit anticorps: primary antibodies
• Clone: SK9, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): flow cytometry: suitable
• Isotype: IgG2bκ
• Numéro d'accès UniProt: P06126
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CD1A(909)

Description

Description générale

CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.

Spécificité

The mouse monoclonal antibody SK9 recognizes an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.

Immunogène

Human thymocytes

Forme physique

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Notes préparatoires

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Stockage et stabilité

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Autres remarques

The antibody solution should be gently mixed before use.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable