SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

• Synonyme(s) : SIGLEC-2, SIGLEC2
• Code UNSPSC : 12352203

Propriétés

• Conjugué: unconjugated
• Niveau de qualité: 100
• Type de produit anticorps: primary antibodies
• Clone: S-HCL-1, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Concentration: 1 mg/ml
• Technique(s): flow cytometry: suitable
• Isotype: IgG2bκ
• Numéro d'accès UniProt: P20273
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CD22(933)

Description

Description générale

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Spécificité

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

Immunogène

Whole hairy cell leukemia cells and membrane preparation

Forme physique

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Notes préparatoires

Purified by protein-A affinity chromatography.

Stockage et stabilité

Store at 2-8°C. Do not freeze.

Autres remarques

The antibody solution should be gently mixed before use.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable