SAB4702015

Monoclonal Anti-CD103 FITC produced in mouse

• Synonyme(s) : ITGAE, Integrin alpha E
• Code UNSPSC : 12352203

Propriétés

• Conjugué: FITC conjugate
• Niveau de qualité: 100
• Type de produit anticorps: primary antibodies
• Clone: Ber-ACT8, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human, ( Non-human primates)
• Technique(s): flow cytometry: suitable
• Isotype: IgG1κ
• Numéro d'accès UniProt: P38570
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ITGAE(3682)

Description

Description générale

CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

Spécificité

The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.

Immunogène

HTLV-1 induced human T cell line MAPS16

Forme physique

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Notes préparatoires

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Stockage et stabilité

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Autres remarques

The antibody solution should be gently mixed before use.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable