SAB4700562

Monoclonal Anti-Cd86-FITC antibody produced in rat

clone GL-1, purified immunoglobulin, buffered aqueous solution

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.44

Propriétés

• Source biologique: rat
• Conjugué: FITC conjugate
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: GL-1, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: mouse
• Concentration: 0.5 mg/mL
• Technique(s): flow cytometry: suitable
• Isotype: IgG2a
• Numéro d'accès NCBI: NM_019388.3
• Numéro d'accès UniProt: P42082
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Informations sur le gène: mouse ... Cd86(12524)

Description

Description générale

Cluster of differentiation 86 (CD86), also known as B7-2, is encoded by the gene mapped to human chromosome 3q13.33. CD86 is a co-stimulatory molecule expressed on various immune cells. The encoded protein belongs to the immunoglobulin (Ig) superfamily.

The rat monoclonal antibody GL-1 reacts with CD86 (B7-2), a 70-80 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

Immunogène

LPS-activated CBA/Cs mouse splenic B cells

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Actions biochimiques/physiologiques

Cluster of differentiation 86 (CD86) plays a vital role in immune responses. Mutations in the gene leads to the development of pneumonia-induced sepsis by downregulating CD86 gene expression in monocytes. Additionally, genetic variation in the gene increases the risk of susceptibility to colorectal cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable