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SAB4700518

Sigma-Aldrich

Monoclonal Anti-CD71-FITC antibody produced in mouse

clone MEM-75, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-TFRC, Anti-Transferrin Receptor

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100 TEST
277.00 CHF

277.00 CHF


Date d'expédition estimée le15 avril 2025



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100 TEST
277.00 CHF

About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

277.00 CHF


Date d'expédition estimée le15 avril 2025


Source biologique

mouse

Niveau de qualité

Conjugué

FITC conjugate

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

MEM-75, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

flow cytometry: suitable

Isotype

IgG1

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TFRC(7037)

Description générale

Transferrin receptor (TFRC, p90) is also known as cluster of differentiation 71 (CD71). The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. In human chromosome, the gene TFRC is localized on 3q29.

Immunogène

NALM-6 human pre-B cell line

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Actions biochimiques/physiologiques

Transferrin receptor (TFRC, CD71) facilitates the uptake of iron bound to transferrin (Tf) through clathrin-mediated endocytosis. TFRC interacts with iron-bound holo-transferrin at pH 7.4 and does not interact apo-transferrin. TFRC also binds with H-ferritin. Expression level of TFRC is regulated stringently by intracellular iron levels. The expression is higher in erythroblasts owing to haemoglobin synthesis. The expression is also higher in cancer cells, osteoclasts and activated lymphocytes, where iron requirement is high. Hypoxia and iron deficiency also increases TFRC expression. Recycling of Tf and TFRC is essential for the uptake of iron from the serum. Mutations in the internalization motif of TFRC leads to impaired endocytosis and consequently congenital/combined immunodeficiency. Improper palmitoylation of TFRC is connected to neurodegeneration with brain iron accumulation. Upregulation of TFRC is implicated in progression of pancreatic cancer, adult T-cell leukemia/lymphoma (ATLL), and cholangiocarcinoma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool
Jamnongkan W, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(7), 1-10 (2017)
Impaired transferrin receptor palmitoylation and recycling in neurodegeneration with brain iron accumulation
Drecourt A, et al.
American Journal of Human Genetics, 102(2), 266-277 (2018)
Transferrin and transferrin receptors update
Kawabata H
Free Radical Biology & Medicine (2018)
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukaemia and deleted in solid tumours
Kashuba VI, et al.
Febs Letters, 419(2-3), 181-185 (1997)
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency
Jabara HF, et al.
Nature Genetics, 48(1), 74-74 (2016)

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