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SAB4504176

Sigma-Aldrich

Anti-phospho-ERK8 (pThr175+Tyr177) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ERK7, MAPK15

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 59 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q8TD08

Numéro d'accès UniProt

Q8TD08

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pThr175+pTyr177)

Informations sur le gène

human ... MAPK15(225689)

Catégories apparentées

Description générale

Mitogen-activated protein (MAP) kinase 15 (MAPK15) or extracellular signal-regulated kinase 8 (ERK8) belongs to the MAP kinase family. MAPK15 gene is located on human chromosome 8q24.3.

Immunogène

The antiserum was produced against synthesized peptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177.

Immunogen Range: 141-190

Actions biochimiques/physiologiques

Extracellular signal-regulated kinase 8 (ERK8)/mitogen-activated protein (MAP) kinase 15 aids in maintaining the integrity of the genome. Anaplastic thyroid carcinoma cells show high expression of MAPK15. It controls telomerase reverse transcriptase (hTERT) mRNA expression to regulate telomerase activity. It is highly essential to control the generation of reactive oxygen species. MAPK15 also plays a role in stabilizing proliferating cell nuclear antigen protein. MAPK15 might be involved in the progression of human cancer. Hence it might act as a candidate as an attractive target for cancer therapy.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Dong-Hao Jin et al.
Oncotarget, 6(24), 20190-20203 (2015-06-03)
This study was aimed at understanding the functional and clinicopathological significance of MAPK15 alteration in gastric cancer. Genome-wide copy number alterations (CNAs) were first investigated in 40 gastric cancers using Agilent aCGH-244K or aCGH-400K, and copy number gains of MAPK15
David Colecchia et al.
The Journal of biological chemistry, 293(41), 15962-15976 (2018-08-23)
Autophagy, a pathway for bulk protein degradation and removal of damaged organelles, represents one of the major responses of cells to stress, thereby exerting a strict control on their correct functioning. Consequently, this process has been involved in the pathogenesis

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