SAB4502262

Anti-PPAR-γ antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : NR1C3, PPAR-γ-1, Peroxisome proliferator activated receptor γ
• Numéro MDL: MFCD01092470
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 57 kDa
• Espèces réactives: mouse, rat, human
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès NCBI: P37231
• Numéro d'accès UniProt: P37231
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PPARG(5468)

Description

Description générale

Peroxisome proliferator-activated receptor γ (PPARγ) is one of the subtypes of PPAR, and belongs to the nuclear hormone receptor superfamily. PPARγ is further sub classified into four isoforms and they have tissue specific expression. PPARγ is encoded by the gene mapped to human chromosome 3p25. PPARγ contains N- terminal AF (activation function)-1 transactivation domain, followed by a DNA-binding domain and a dimerization and ligand-binding domain.

Immunogène

The antiserum was produced against synthesized peptide derived from human PPAR-gamma.

Immunogen Range: 78-127

Actions biochimiques/physiologiques

Peroxisome proliferator-activated receptor γ (PPARγ) induces the expression of genes coding for proteins implicated in glucose and lipid metabolism. Natural PPAR-γ agonists found in foods functions as an anti-inflammatory molecule, thus, PPARγ is not only a target of the pharmaceutical industry, but also a novel target of the food industry. PPAR-γ regulates energy storage, adipocyte differentiation, and cellular inflammatory and ischemic responses. PPARγ is also involved in the production of prostanoids that regulate vascular function. PPARγ agonists, thiazolidinediones including rosiglitazone and pioglitazone, enhance insulin sensitivity by inhibiting the tumor necrosis factor α (TNF-α) activity in adipocytes. These PPAR-γ agonists are used in the treatment of type 2 diabetes. PPARγ functions as a potential therapeutic target in pulmonary hypertension.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable