SAB4501764
Anti-Lamin A antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
70 kDa lamin, LAMA, LMN1, LMNA
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About This Item
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 74 kDa
Espèces réactives
mouse, human, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... LMNA(4000)
Catégories apparentées
Description générale
Lamin A/C (LMNA) gene codes for lamin A and C. Lamin A/C is a nuclear intermediate filament protein. LMNA gene is mapped to human chromosome 1q22. Anti-Lamin A Antibody detects endogenous levels of total Lamin A protein.
Immunogène
The antiserum was produced against synthesized peptide derived from human Lamin A/C.
Immunogen Range: 361-410
Immunogen Range: 361-410
Application
Anti-Lamin A antibody produced in rabbit has been used in immunoblotting.
Actions biochimiques/physiologiques
Lamin A/C (LMNA) is involved in the structural organization of the nucleus. It modulates gene expression. It may play a role in osteoblastogenesis. Mutation in the LMNA gene is associated with muscle dystrophies, cardiomyopathies, lipodystrophies, and neuropathies. LMNA protein plays a vital role in cell cycle progression. It controls extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and Wnt β-catenin pathway.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Halida P Widyastuti et al.
BMC medical genetics, 21(1), 152-152 (2020-07-24)
Intermediate filament proteins that construct the nuclear lamina of a cell include the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental processes such as nuclear structure, gene expression, and signal transduction. LMNA mutations predominantly affect
Anna Sowińska-Seidler et al.
Journal of applied genetics, 59(3), 281-289 (2018-05-31)
Craniosynostosis (CS) refers to the group of craniofacial malformations characterized by the premature closure of one or more cranial sutures. The disorder is clinically and genetically heterogeneous and occurs usually as an isolated trait, but can also be syndromic. In
Hin Chu et al.
The Journal of biological chemistry, 293(30), 11709-11726 (2018-06-12)
Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and the host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related coronaviruses can recognize distinct receptors, whereas spikes
Elena V Ignatieva et al.
Genes, 11(9) (2020-09-11)
Laminopathies are a family of monogenic multi-system diseases resulting from mutations in the LMNA gene which include a wide range of neuromuscular disorders. Although lamins are expressed in most types of differentiated cells, LMNA mutations selectively affect only specific tissues
Lorenzo Bazzani et al.
Oncotarget, 9(19), 14939-14958 (2018-03-31)
Prostaglandin E2 (PGE2) contributes to tumor progression by promoting cancer cell growth, invasion and by creating a favorable pro-tumor microenvironment. PGE2 has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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