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SAB4500895

Sigma-Aldrich

Anti-ATF5 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ATF5, Activating transcription factor 5, Cyclic AMP-dependent transcription factor ATF-5, Transcription factor ATFx, cAMP-dependent transcription factor ATF-5

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 30 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q9Y2D1

Numéro d'accès UniProt

Q9Y2D1

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ATF5(22809)

Description générale

Activating transcription factor 5 (ATF5) belongs to the ATF/cAMP response element-binding protein family. It is an anti-apoptotic protein that has 282 amino acids and is located on human chromosome 19q13. It is expressed in various cancers like prostate, rectal, colon, endometrium, breast, ovary, pancreas, gastric etc.
Anti-ATF5 Antibody detects endogenous levels of total ATF5 protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human ATF5.

Immunogen Range: 221-270

Actions biochimiques/physiologiques

Activating transcription factor 5 (ATF5) participates in metabolite homeostasis, cellular proliferation, differentiation, apoptosis and regulation of the cell cycle. It controls neural progenitor cell and adipose-derived stem cell differentiation.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Ishihara S, et al.
Oncotarget, 6, 4602-4614 (2015)
ATF5 (activating transcription factor 5)
Ching A KK and Wong N
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
DNA methylation level of promoter region of activating transcription factor 5 in glioma
Hua XM, et al.
Journal of Zhejiang University. Science. B, 16, 757-762 (2015)
Role of ATF5 in the invasive potential of diverse human cancer cell lines
Nukuda A, et al.
Biochemical and Biophysical Research Communications, 474, 509-514 (2016)
Kari A Gaither et al.
PloS one, 15(6), e0225044-e0225044 (2020-07-01)
Cellular stress response mechanisms normally function to enhance survival and allow for cells to return to homeostasis following an adverse event. Cancer cells often co-opt these same mechanisms as a means to evade apoptosis and mitigate a state of constant
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