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Merck
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Key Documents

SAB4300427

Sigma-Aldrich

Anti-PAK1 (Ab-212) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-MGC130000 antibody produced in rabbit, Anti-MGC130001 antibody produced in rabbit, Anti-PAKalpha antibody produced in rabbit, Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD03457569
Code UNSPSC :
12352203

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~68 kDa

Espèces réactives

human, mouse, rat

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(P-V-T-P-T)

Numéro d'accès NCBI

NP_001122092.1

Numéro d'accès UniProt

Q13153

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PAK1(5058)

Immunogène

Peptide sequence around aa. 210-214 (P-V-T-P-T), according to the protein PAK1.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Fariborz Mortazavi et al.
BMC cancer, 15, 381-381 (2015-05-10)
Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC). We used NSCLC clinical specimens to
Matthew Rettig et al.
PloS one, 7(7), e42012-e42012 (2012-08-01)
The role of c-Crk (CRK) in promoting metastasis is well described however the role of CRK phosphorylation and the corresponding signaling events are not well explained. We have observed CRK-II serine 41 phosphorylation is inversely correlated with p120-catenin and E-cadherin
Gholam H Pezeshkpour et al.
Genes & cancer, 4(7-8), 315-324 (2013-10-30)
CRK (c-Crk) as an adaptor protein is involved in several oncogenic signal transduction pathways, conveying oncogenic signals to its downstream effectors and thereby affecting multiple cellular processes including proliferation, differentiation, and migration. For example, we have observed that CRK expression

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