SAB4300056

Anti-phospho-PGR (pSer¹⁹⁰) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-NR3C3 antibody produced in rabbit, Anti-PR antibody produced in rabbit, Anti-progesterone receptor antibody produced in rabbit
• Numéro MDL: MFCD00239723
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~99 kDa
• Espèces réactives: human
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (G-L-SP-P-A)
• Numéro d'accès NCBI: NP_000917.3
• Numéro d'accès UniProt: P06401
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer190)
• Informations sur le gène: human ... PGR(5241)

Description

Immunogène

Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A), according to the protein PGR.

Caractéristiques et avantages

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Description de la cible

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable