SAB4300031

Anti-phospho-GATA1 (pSer³¹⁰) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-ERYF1 antibody produced in rabbit, Anti-GATA binding protein 1 (globin transcription factor 1) antibody produced in rabbit, Anti-GF-1 antibody produced in rabbit, Anti-GF1 antibody produced in rabbit, Anti-NFE1 antibody produced in rabbit
• Numéro MDL: MFCD02096392
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~43 kDa
• Espèces réactives: rat, mouse, human
• Concentration: 1 mg/mL
• Technique(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (K-A-SP-G-K)
• Numéro d'accès NCBI: NP_002040.1
• Numéro d'accès UniProt: P15976
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer310)
• Informations sur le gène: human ... GATA1(2623)

Description

Description générale

GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family.

Immunogène

Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1.

Actions biochimiques/physiologiques

GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.

Caractéristiques et avantages

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Description de la cible

GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable