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SAB4200806

Sigma-Aldrich

Anti-Ezrin antibody, Mouse monoclonal

clone 3C12, purified from hybridoma cell culture

Synonyme(s) :

Cytovillin, Villin-2, p81

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

3C12, monoclonal

Forme

buffered aqueous solution

Poids mol.

~80 kDa

Espèces réactives

bovine, canine, hamster, kangaroo, human, monkey, rat, mouse

Conditionnement

antibody small pack of 25 μL

Concentration

~1 mg/mL

Technique(s)

immunoblotting: 1-2 μg/mL using using canine MDCK cells extract
immunofluorescence: 0.5-1  μg/mL using human epidermoid carcinoma A431 cells.

Isotype

IgG1

Numéro d'accès UniProt

P15311

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Ezr(22350)

Description générale

Ezrin, also known as cytovillin, p81 or 80K, is a.member of the ERM proteins family composed of Ezrin, Radixin, and Moesin. These proteins are known as actin-binding proteins that link the cell membrane to the actin cytoskeleton, particularly in microvillus-bearing epithelial cells. Ezrin is present in microvilli, microspikes, and membrane ruffles of cells.
The ERM proteins family are involved in the functional expression of membrane proteins on the cell surface, integrate Rho guanosine 5′-triphosphatase (GTPase) signaling regulating cytoskeletal organization and act as protein kinase A (PKA)-anchoring proteins. Therefore, ERM proteins seem to play an important role in the membrane transport of electrolytes by ion channels and transporters.

Immunogène

The carboxy-terminal part of recombinant human ezrin

Application

Monoclonal Anti-Ezrin recognizes an epitope located on the C-terminal region of Ezrin. Reactivity has been observed with human, mouse, hamster, monkey, bovine, canine, rat and rat-kangaroo origin. The antibody is recommended to use in various immunological techniques, including Immunoblotting (~80kDa), immunofluorescence, Immunohistochemistry and immunoprecipitation.

Forme physique

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Autres remarques

This product is for R&D use only, not for drug, household, or other uses.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Elena Leveringhaus et al.
Emerging microbes & infections, 13(1), 2327385-2327385 (2024-03-22)
Several cellular factors have been reported to be required for replication of classical swine fever virus (CSFV), a member of the genus Pestivirus within the family Flaviviridae. However, many steps of its replication cycle are still poorly understood. The low-density

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