SAB4200160

Anti-Synaptotagmin 7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-IPCA-7, Anti-PCANAP7, Anti-SYT-VII, Anti-SYT7
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~45 kDa
• Espèces réactives: mouse, human
• Validation améliorée: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentration: ~1.0 mg/mL
• Technique(s): western blot: 1-2 μg/mL using mouse brain extracts (S1 fraction) and HEK-293T cell lysates expressing human synaptotagmin 7
• Numéro d'accès UniProt: O43581
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Informations sur le gène: human ... SYT7(9066) ; mouse ... Syt7(54525)

Description

Description générale

Synaptotagmin 7, also known as Syt7, is a transmembrane Ca²⁺ binding protein. It belongs to synaptotagmin family of proteins. Syt7 contains a single transmembrane domain, a variable linker sequence and C2A and C2B Ca²⁺-binding domains. Syt7 is ubiquitously expressed during development but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.

Application

Anti-Synaptotagmin 7 antibody produced in rabbit has been used in immunoblotting.

Actions biochimiques/physiologiques

Synaptotagmins regulates membrane or vesicular trafficking, including synaptic vesicle (SV) exocytosis. Synaptotagmin 7 plays a vital role in regulation of Ca²⁺-dependent lysosome exocytosis. Syt7 is expressed in pancreatic β-cells and has been suggested to function as a Ca²⁺ sensor regulating insulin secretion. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable