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SAB2501514

Sigma-Aldrich

Anti-KLHL6 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-FLJ00029, Anti-kelch-like 6, Kelch-like 6 (Drosophila), Kelch-like protein KLHL6

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat, canine, human, mouse

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q8WZ60

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KLHL6(89857)

Description générale

Kelch-like protein 6 (KLHL6) is a member of BTB (broad-complex, tramtrack and bric à brac)-kelch protein family. The gene encoding this protein is mapped to human chromosome 3q27. The encoded protein expression is confined to lymphoid tissue. KLHL6 exhibits high activity within the germinal center of B cells. The protein structure consists of a BTB domain at N terminal and six kelch repeats at the C terminal. KLHL6 protein is primarily expressed in human tonsil B lymphocytes.
Kelch-like protein 6 (KLHL6) plays a vital role in B-cell receptor (BCR) cell signaling and differentiation pathway of germinal center within B- cells. Aberration in the expression of this protein leads to chronic lymphocytic leukemia (CLL).

Immunogène

Peptide with sequence SERTKPRMHEFQSE, from the internal region of the protein sequence according to NP_569713.2

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Update on the Kelch-like (KLHL) gene family.
Dhanoa BS
Human Genomics (2013)
Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.
Gupta-Rossi N
Molecular Immunology (2003)
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
Sharma PR
Endocrinology (2015)
The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Kroll J
Molecular and Cellular Biology (2005)
Mandeep Singh et al.
Cell, 180(5), 878-894 (2020-02-16)
Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies responsible

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