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Principaux documents

COO/COA

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S1315

L-Serine

Name: <SC>L</SC>-Serine
Brand: SIGMA

Synonyme(s) :

(S)-2-Amino-3-hydroxypropionic acid

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About This Item

Formule linéaire :

HOCH₂CH(NH₂)CO₂H

Numéro CAS:

56-45-1

Poids moléculaire :

105.09

Beilstein:

1721404

Numéro CE :

200-274-3

Numéro MDL:

MFCD00064224

Code UNSPSC :

12352209

Source biologique

non-animal source

Essai

≥98.5%

Fabricant/nom de marque

Ajinomoto

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Pf

222 °C (dec.) (lit.)

Solubilité

H₂O: 50 mg/mL

Adéquation

suitable for manufacturing use

Application(s)

pharmaceutical (small molecule)

Chaîne SMILES

N[C@@H](CO)C(O)=O

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

Clé InChI

MTCFGRXMJLQNBG-REOHCLBHSA-N

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Description générale

To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.

Application

L-Serine is classified as a non-essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Actions biochimiques/physiologiques

Precursor of glycine by serine hydroxymethyltransferase.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

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Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.

Kenji Hashimoto et al.

Progress in neuro-psychopharmacology & biological psychiatry, 29(5), 767-769 (2005-06-09)

Several lines of evidence suggest that D-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of D- and

A peptide hormone and its receptor protein kinase regulate plant cell expansion.

Miyoshi Haruta et al.

Science (New York, N.Y.), 343(6169), 408-411 (2014-01-25)

Plant cells are immobile; thus, plant growth and development depend on cell expansion rather than cell migration. The molecular mechanism by which the plasma membrane initiates changes in the cell expansion rate remains elusive. We found that a secreted peptide

L-serine in disease and development.

Tom J de Koning et al.

The Biochemical journal, 371(Pt 3), 653-661 (2003-01-22)

The amino acid L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long

Memory recall and modifications by activating neurons with elevated CREB.

Jieun Kim et al.

Nature neuroscience, 17(1), 65-72 (2013-11-12)

Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into

Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.

Chang-Ching Liu et al.

Molecular and cellular biology, 34(1), 57-70 (2013-10-30)

In budding yeast (Saccharomyces cerevisiae), the cell cycle-dependent telomere elongation by telomerase is controlled by the cyclin-dependent kinase 1 (Cdk1). The telomere length homeostasis is balanced between telomerase-unextendable and telomerase-extendable states that both require Cdc13. The recruitment of telomerase complex

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Chromatograms

HPLC Analysis of FMOC-Serine Enantiomers on Astec^® (R,R) P-CAP^™

application for HPLC

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