R4282

RF9 trifluoroacetate salt

≥97% (HPLC)

• Synonyme(s) : 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
• Formule empirique (notation de Hill) : C₂₆H₃₈N₆O₃ · xC₂HF₃O₂
• Numéro CAS: 876310-60-0
• Poids moléculaire : 482.62 (free base basis)
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824030
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥97% (HPLC)
• Solubilité: H₂O: 20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1
• Clé InChI: GPVFYPYIOXHDCU-CFIUKZCSSA-N

Description

Actions biochimiques/physiologiques

RF9 is a neuropeptide FF receptor antagonist.

RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)