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PRS4307

Sigma-Aldrich

Anti-STEAP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Six transmembrane epithelial antigen of the prostate 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

predicted mol wt 54 kDa

Espèces réactives

mouse, human

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q8NFT2

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... STEAP2(261729)

Description générale

The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a metalloreductase that belongs to the STEAP family. It is localized in secretory and endocytic pathway organelles. The STEAP2 gene is mapped to human chromosome 7q21.13.

Immunogène

a 16 amino acid peptide from near the carboxy-terminus of human STEAP2.

Actions biochimiques/physiologiques

The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) being localized in Golgi membrane and cytoplasmic vesicles, may have a critical role in the endocytic pathway. It is highly expressed in prostate carcinomas (PCa) and promotes tumor invasion and migration. Along with STEAP3 and 4, STEAP2 levels are implicated in favoring copper and iron uptake. Studies on targeted STEAP2 knockdown have reported a reduction in PCa progression.

Liaison

The action of this antibody can be blocked using blocking peptide SBP4307.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Shadia M Ihlaseh-Catalano et al.
Histopathology, 63(5), 678-685 (2013-09-13)
To investigate the prognostic value of expression levels of the genes STEAP1 and STEAP2, and of STEAP1 protein, in prostate carcinomas (PCa). STEAP1 and STEAP2 transcript levels were evaluated by RT-qPCR in samples from 35 PCa, 24 adjacent non-neoplastic prostate
Stephanie E A Burnell et al.
Scientific reports, 8(1), 6252-6252 (2018-04-21)
Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate
Haruki Hasegawa et al.
Experimental cell research, 370(2), 208-226 (2018-06-26)
STEAP2 is a member of the Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) protein family that is proposed to function as metalloreductase. While STEAP2 shows a complex subcellular distribution pattern localizing to both secretory and endocytic pathway organelles, how such

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