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PLA0100

Sigma-Aldrich

Rabbit anti-MLL1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonyme(s) :

ALL-1, CDK6/MLL fusion protein, CXXC-type zinc finger protein 7, CXXC7, HRX, HTRX1, MLL, MLL-AF4 der(11) fusion protein, MLL-AF9, MLL/ENL fusion protein, MLL/GAS7, MLL/GAS7 fusion protein, MLL/GMPS fusion protein, MLL/hCDCrel fusion protein, MLL1, MLL1A, Myeloid/lymphoid or mixed-lineage leukemia, TET1-MLL, TRX1, WDSTS, lysine (K)-specific methyltransferase 2A, lysine N-methyltransferase 2A, mixed lineage leukemia 1, rearranged MLL protein, trithorax-like protein, zinc finger protein HRX

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.43

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Qualité

Powered by Bethyl Laboratories, Inc.

Espèces réactives

human

Technique(s)

ChIP: 1- 5 μg
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000

Numéro d'accès

Q03164

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rabbit ... MLL1(4297)

Description générale

MLL1 (mixed-lineage leukemia) gene is also referred as KMT2A (lysine methyltransferase 2A) and is located on human chromosome locus 11q23.3.

Immunogène

The epitope recognized by PLA0100 maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).

Actions biochimiques/physiologiques

MLL1 (mixed-lineage leukemia) is a histone methyltransferase and has a role in embryogenesis and hematopoiesis. MLL1 is a transcriptional co-activator and regulates epigenetic gene expression through chromatin modification. MLL1 is associated with NF-κB (nuclear factor kappa B) pathway- induced brain tumor proliferation. On the other hand, MLL1 is known to prevent metastasis and invasion in cervical cancer.

Forme physique

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Autres remarques

MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
Tarlock K, et al.
Clinical Cancer Research, 23(14), 3649-3656 (2017)
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.
Zhang C, et al.
Cell Death & Disease, 8(7), e2940-e2940 (2017)
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.
Grey W, et al.
Biochimica et Biophysica Acta, 1865(1), 105-116 (2018)
Yan Jin et al.
PLoS biology, 19(6), e3001297-e3001297 (2021-06-11)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (designated as

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