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P7679

Sigma-Aldrich

Monoclonal Anti-Platelet-Derived Growth Factor Receptor β antibody produced in mouse

clone PDGFR-B2, ascites fluid

Synonyme(s) :

Anti-PDGF Rβ

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About This Item

Numéro MDL:
MFCD00164777
Code UNSPSC :
51111800

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Clone

PDGFR-B2, monoclonal

Contient

15 mM sodium azide

Espèces réactives

human, pig

Technique(s)

immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:100 using denatured, non-reduced porcine uterus extract

Isotype

IgG2b

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... PDGFRB(5159)

Spécificité

The antibody recognizes human and pig PDGF Rβ, but not mouse or rat. It can be used for immunoperoxidase and immunofluorescence staining of unfixed or acetone-fixed frozen tissue. The antibody induces clustering and down-regulation of PDGF Rβ. The antibody does not cross react with PDGF Rα.

Immunogène

PDGF β-receptor from pig uterus.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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C Reuterdahl et al.
Laboratory investigation; a journal of technical methods and pathology, 64(3), 321-329 (1991-03-01)
Platelet-derived growth factor (PDGF) beta-receptor expression in normal and rheumatoid synovia was investigated by double immunofluorescence staining of frozen sections and by in situ hybridization. In the inflamed synovia, PDGF beta-receptor mRNA was present in vascular cells, as well as
P Höddelius et al.
Bioscience reports, 20(2), 119-127 (2000-08-31)
When the receptors for platelet-derived growth factor (PDGF) are activated they aggregate, become tyrosine-phosphorylated and elicit a cascade of down-stream signals, including mobilization of Ca2+ from intra- and extracellular stores. Receptor mobility in the plane of the membrane is a
A Sorkin et al.
The Journal of cell biology, 112(3), 469-478 (1991-02-01)
The complementary DNAs for wildtype and tyrosine kinase-inactivated (K634A) forms of the PDGF beta-receptor were expressed in porcine aortic endothelial cells. We examined the internalization and degradation of ligands and receptors after exposure of receptor expressing cells to PDGF-BB, which
Mikhail Sergeev et al.
Biophysical journal, 91(10), 3884-3896 (2006-08-29)
We present higher-order moment analysis of fluorescence intensity fluctuations from individual laser scanning microscopy images applied to study monomer-oligomer distributions. We demonstrate that the number densities and brightness ratios of a mixed population of monomers and oligomers can be determined
Jonathan W D Comeau et al.
Biophysical journal, 91(12), 4611-4622 (2006-10-03)
Biomolecular interactions are fundamental to the vast majority of cellular processes, and identification of the major interacting components is usually the first step toward an understanding of the mechanisms that govern various cell functions. Thus, statistical image analyses that can
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