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P3761

Sigma-Aldrich

Pentobarbital sodium salt

Synonyme(s) :

5-Ethyl-5-(1-methylbutyl)-2,4,6-trioxohexahydropyrimidine, Nembutal

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About This Item

Formule empirique (notation de Hill):
C11H17N2NaO3
Numéro CAS:
57-33-0
Poids moléculaire :
248.25
Numéro CE :
200-323-9
Numéro MDL:
MFCD00070198
Code UNSPSC :
41116107
ID de substance PubChem :
24898448

Forme

powder

Contrôle du médicament

USDEA Schedule II; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

Solubilité

H2O: soluble
alcohol: soluble

Chaîne SMILES 

[Na].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O

InChI

1S/C11H18N2O3.Na.H/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);;

Clé InChI

PGOYUXGHADTNIB-UHFFFAOYSA-N

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Application

Pentobarbital sodium salt has been used as an anesthetic in rats and mice prior to various in vitro studies.

Actions biochimiques/physiologiques

Pentobarbital (PB) is a barbiturate and a ligand of the γ-aminobutyric acid subtype A (GABAA) receptor. It is a sedative anesthetic majorly used in rodent euthanasia. Pentobarbital possesses hypnotic functionality and muscle relaxing properties. It enhances GABAergic activity. Intraperitoneal injection of PB may result in loss of righting reflex (LORR) and heartbeat cessation.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H336,H361d

Classification des risques

Acute Tox. 3 Oral - Repr. 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Issei Takeuchi et al.
Colloids and surfaces. B, Biointerfaces, 155, 35-40 (2017-04-10)
Postmenopausal osteoporosis among older women, which occurs by an ovarian hormone deficiency, is one of the major public health problems. 17 β-estradiol (E2) is used to prevent and treat this disease as a drug of hormone replacement therapy. In oral
Martina Ceckova et al.
Antimicrobial agents and chemotherapy, 60(9), 5563-5572 (2016-07-13)
Lamivudine is one of the antiretroviral drugs of choice for the prevention of mother-to-child transmission (MTCT) in HIV-positive women. In this study, we investigated the relevance of drug efflux transporters P-glycoprotein (P-gp) (MDR1 [ABCB1]), BCRP (ABCG2), MRP2 (ABCC2), and MATE1
Minfeng Chen et al.
The Journal of clinical investigation, 127(10), 3689-3701 (2017-08-29)
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads to a viable peripheral tumor rim that contributes to treatment failure and disease recurrence. Here, we provide evidence
Issei Takeuchi et al.
Bio-medical materials and engineering, 27(5), 475-483 (2016-11-26)
Estradiol is one of the therapeutic agents for osteoporosis. We have reported transdermal permeability of estradiol-loaded nanoparticles, and permeability effect of estradiol was enhanced by using nanoparticle system and iontophoresis [Colloids and Surfaces B: Biointerfaces97 (2012), 84-89]. This study was
Hiroshi Hasegawa et al.
The International journal of oral & maxillofacial implants, 34(2), 411-422 (2019-03-19)
This study aimed to evaluate the safety and efficacy of newly designed, laser-perforated pure titanium membranes for guided bone regeneration and to compare them with an existing product, the FRIOS BoneShield (FBS). Acute-type lateral ridge defects were bilaterally created in
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