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P0034

20S-Protopanaxatriol

Name: 20S-Protopanaxatriol
Brand: SIGMA

Synonyme(s) :

20(S)-APPT, g-PPT

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About This Item

Formule empirique (notation de Hill):

C₃₀H₅₂O₄

Numéro CAS:

34080-08-5

Poids moléculaire :

476.73

Numéro MDL:

MFCD11041271

Code UNSPSC :

12352200

Forme

powder

Niveau de qualité

200

Température de stockage

2-8°C

InChI

1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28-,29+,30-/m0/s1

Clé InChI

SHCBCKBYTHZQGZ-PHFGEWBZSA-N

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Description générale

A ginsenoside metabolite that has been linked to endothelial cell function via the glucocortoid receptor (GR) and the oestrogen receptor (ER).

Application

20S-Protopanaxatriol (g-PPT), a dammarane-type tetracyclic terpene sapogenin, may be used to study its binding to and modulation of cell function via glucocortoid (GR) and oestrogen (ER) receptors.

Actions biochimiques/physiologiques

A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Spinal estrogen receptor alpha mediates estradiol-induced pronociception in a visceral pain model in the rat.

Yaping Ji et al.

Pain, 152(5), 1182-1191 (2011-03-12)

We previously reported that 17β-estradiol (E2) is pronociceptive in a visceral pain model in the rat. Subcutaneously (s.c.) administered E2 reversed the decrease in the colorectal distention (CRD)-evoked visceromotor response produced by ovariectomy (OVx) and CRD-induced nociceptive responses were greater

Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats.

Jessica Santollo et al.

Physiology & behavior, 97(2), 193-198 (2009-03-04)

Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To

Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes.

Kyu Lee Han et al.

Biological & pharmaceutical bulletin, 29(1), 110-113 (2006-01-06)

Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor of ligand-activated transcription factors, regulates the expression of key genes involved in lipid and glucose metabolism or adipocyte differentiation. Ligands for this receptor have emerged as potent insulin sensitizers

Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.

Rui Liu et al.

Fitoterapia, 81(8), 1079-1087 (2010-07-16)

Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of

Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase.

So Young Hong et al.

Journal of agricultural and food chemistry, 60(12), 3086-3091 (2012-03-03)

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a fundamental regulator of systemic blood pressure. Ginsenosides from Panax ginseng have been investigated in vitro for the molecular and biochemical mechanisms by which they stimulate NO release in

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