M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
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About This Item
Code UNSPSC :
12161501
Nomenclature NACRES :
NA.47
Produits recommandés
Source biologique
mouse (CD-1)
Niveau de qualité
Forme
liquid
Conditionnement
vial of ~10 mg
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
mouse ... Mgst1(56615)
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Description générale
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Application
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.
Actions biochimiques/physiologiques
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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