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L7877

Sigma-Aldrich

Lactulose

≥95% (HPLC)

Synonyme(s) :

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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About This Item

Formule empirique (notation de Hill):
C12H22O11
Numéro CAS:
4618-18-2
Poids moléculaire :
342.30
Numéro Beilstein :
93773
Numéro CE :
225-027-7
Numéro MDL:
MFCD00151469
Code UNSPSC :
12352201
ID de substance PubChem :
24896485
Nomenclature NACRES :
NA.25

Source biologique

synthetic

Pureté

≥95% (HPLC)

Forme

powder

Activité optique

[α]20/D -52.0 to -48.0 °, c = 4% (w/v) in water

Couleur

white to off-white

Pf

169  °C ((336 °F ))

Solubilité

water: 50 mg/mL, clear, colorless to faintly yellow

Température de stockage

room temp

Chaîne SMILES 

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

Clé InChI

JCQLYHFGKNRPGE-WJONTELPSA-N

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Actions biochimiques/physiologiques

Lactulose is a synthetic disaccharide derived from galactose and fructose. It is not absorbed in the gut and is frequently used in the treatment of constipation and hepatic encephalopathy. Studies have reported that lactulose administration may cause an increase in fecal nitrogen. It is also known to function as a prebiotic. Lactulose measurements can be used to detect gastrointestinal dysfunctions.

Autres remarques

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Huifang Yin et al.
Carbohydrate research, 465, 58-65 (2018-06-27)
Oligosaccharides derived from lactulose (β-D-Galp-(1 → 4)-D-Fru) are drawing more and more attention nowadays because of their strong resistance to gut digestion, and the interest to discover novel prebiotics. Compared to galactooligosaccharides, currently known structures of lactulose oligosaccharides are very limited. In
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
Edwin R Price et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(2), 351-355 (2012-11-21)
Flying vertebrates have been hypothesized to have a high capacity for paracellular absorption of nutrients. This could be due to high permeability of the intestines to nutrient-sized molecules (i.e., in the size range of amino acids and glucose, MW 75-180
Xiao Hua et al.
Food chemistry, 137(1-4), 1-7 (2012-12-04)
Production of 1-lactulose and lactulose using commercial β-galactosidase DSM Maxilact® 5000 in the presence of fructose was investigated. Experiments were performed at 40 °C and pH 7.5. Lactose starting concentration was constantly 250 g/l. A novel transgalactosylation product 1-lactulose was
C P Kelly et al.
Alimentary pharmacology & therapeutics, 37(2), 252-262 (2012-11-21)
Coeliac disease, an autoimmune disorder triggered by gluten ingestion, is managed by a gluten-free diet (GFD), which is difficult for many patients. Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and
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