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L4794

Sigma-Aldrich

Anti-Lysyl Oxidase antibody produced in rabbit

enhanced validation

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Lysyl Oxidase Antibody, Lysyl Oxidase Antibody - Anti-Lysyl Oxidase antibody produced in rabbit, Anti-LOX, Anti-Protein lysine 6-oxidase

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~50 kDa

Espèces réactives

human

Validation améliorée

recombinant expression
Learn more about Antibody Enhanced Validation

Concentration

~1 mg/mL

Technique(s)

western blot: 1.5-3.0 μg/mL using HEK-293T cells expressing human LOX

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LOX(4015)
mouse ... Lox(16948) , Lox(24914)

Catégories apparentées

Description générale

The gene LOX (lysyl oxidase) encodes a copper-dependent amine oxidase that belongs to LOX family of proteins. These proteins contain highly conserved C- terminal mature catalytic domains that include the copper binding site, the lysyl tyrosyl quinine (LTQ) cofactor residues, and the cytokine receptor like (CRL) domain. It is present in both intercellular and intracellular locations.

Spécificité

Rabbit polyclonal anti-Lysyl Oxidase antibody specifically recognizes human lysyl oxidase (LOX). Detection of the LOX band by immunoblotting is specifically inhibited by the LOX immunizing peptide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Actions biochimiques/physiologiques

The gene LOX (lysyl oxidase) encodes an extracellular matrix remodeling enzyme that catalyzes the oxidation of primary amino group of peptidyl lysine to reactive peptidyl aldehydes. It is mainly involved in the oxidation of lysine residues in elastin and collagen, resulting in the formation of covalent cross-linkages, which stabilize these fibrous proteins. It also plays a role in several cellular processes such as developmental regulation, tumor suppression, cell motility, and cellular senescence. It is involved in hypoxia-induced metastasis and serves as a therapeutic target for the treatment of metastases.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Noelia Agra et al.
PloS one, 8(6), e66281-e66281 (2013-06-12)
Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate and downregulate target genes, leading to cellular transformation. Thus, identificating
Lysyl oxidase, extracellular matrix remodeling and cancer metastasis.
Xiao Q and Ge G
Cancer Microenvironment, 5, 261-273 (2012)
Lysyl oxidases: a novel multifunctional amine oxidase family.
Csiszar K
Prog. Nucleic Acids Res. Mol. Biol., 70, 1-32 (2001)
Lysyl oxidase is essential for hypoxia-induced metastasis.
Erler JT
Nature, 440, 1222-1226 (2006)
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.
Kagan HM and Li W
Journal of Cellular Biochemistry, 88, 660-672 (2003)

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