I9401
Interleukin-1β human
IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonyme(s) :
IL-1β, Lymphocyte activating factor
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Numéro MDL:
Code UNSPSC :
12352202
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in E. coli
Essai
≥98% (SDS-PAGE)
Forme
lyophilized powder
Puissance
≤12 pg/mL ED50
Qualité
endotoxin tested
Poids mol.
17.3 kDa
Conditionnement
pkg of 5 and 25 μg
pkg of 25 μg
Technique(s)
cell culture | mammalian: suitable
Couleur
white to off-white
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... IL1B(3553)
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Actions biochimiques/physiologiques
Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses. Other synonyms for IL-1 include: endogenous pyrogen (EP), mitogenic protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFM), B Cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF) The two closely related agents Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) share 62% homology in amino acid sequence and elicit nearly identical biological responses. IL-1α and IL-1β are both approximately 17 kDa with some heterogeneity in the amount of glycosylation.
Forme physique
Lyophilized from a 0.2 μm filtered buffered solution.
Remarque sur l'analyse
The biological activity is measured by the dose-dependent stimulation of MTS cleavage by murine D10S cells.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Janette Bester et al.
Scientific reports, 6, 32188-32188 (2016-08-27)
Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory conditions. Hypercoagulability is an important hallmark of inflammation, and these cytokines are
Nicholas F Lahens et al.
BMC genomics, 18(1), 602-602 (2017-08-12)
Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. Previous investigations of this question have typically used reference samples derived
Tanja Mang et al.
International journal of molecular sciences, 21(2) (2020-01-18)
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective of this study was to
Seong Soo Joo et al.
Biological & pharmaceutical bulletin, 33(11), 1854-1860 (2010-11-05)
In pancreatic islets, free radical formation produced upon exposure to proinflammatory cytokines mediates β cell destruction, which ultimately leads to type 1 diabetes (T1D). In this study, we examined whether laccase, a family of the blue copper protein, can be
Karin Larsson et al.
British journal of pharmacology, 176(24), 4625-4638 (2019-08-14)
Microsomal PGE synthase-1 (mPGES-1), the inducible synthase that catalyses the terminal step in PGE2 biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of mPGES-1 is suggested to be safer than traditional NSAIDs, and recent data demonstrate
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique