HPR116080
Differentiated HepaRG™ Cells Cryopreserved
Liver tumor of female patient diagnosed with hepatocarcinoma and hepatitis
Synonyme(s) :
HepaRG Cell Line
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About This Item
Code UNSPSC :
41106514
Produits recommandés
product name
Differentiated HepaRG™ Cells Cryopreserved,
Source biologique
(Liver tumor of female patient diagnosed with hepatocarcinoma and hepatitis C)
Conditions d'expédition
dry ice
Température de stockage
−196°C
Description générale
HepaRG is a human hepatoma cell line originally derived from a female patient diagnosed with hepatocarcinoma and hepatitis C. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line that has the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG cells are useful as an alternative to human primary cells as they retain the major functional activities of these cells. HepaRG cells express functional levels of the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways. HepaRG cells are fully differentiated and ready to use upon receipt.
Application
See user guide for detailed protocols.
Caractéristiques et avantages
HepaRG cells are useful for many in vitro ADME applications, including drug metabolism,reactive metabolite formation, clearance, CYP inhibition and induction assays. They are also suitable for a variety of in vitro toxicity assays, including general hepatotoxicity, cholestasis,and viral infection. HepaRG cells have recently been grown in bioreactors, used for the generation of hepatic spheroids and been implanted into animals to produce humanized livers. The potential range of applications for HepaRG cells continues to expand at a rapid pace.
Informations légales
Use of this product is subject to one or more license agreements.
HepaRG cells are patented and their use is strictly limited; consider the cells as a single use, disposable product that must be destroyed upon conclusion of a study or experiment. Propagating, reproducing, cloning, subcloning or any other use of the cells following the conclusion of a study is prohibited. Use of the cells to produce or manufacture commercial products for general sale or for use in the manufacture of products intended for general sale is prohibited. Transfer of the cells to anyone not employed within the same organization, whether for financial benefit or not, is prohibited. If you are unwilling to accept the terms of this LIMITED USE LICENSE, do not ORDER or use them, and immediately return the cells for credit. Violators of this Limited Use License will be prosecuted to the fullest extent of the law.
HepaRG cells are patented and their use is strictly limited; consider the cells as a single use, disposable product that must be destroyed upon conclusion of a study or experiment. Propagating, reproducing, cloning, subcloning or any other use of the cells following the conclusion of a study is prohibited. Use of the cells to produce or manufacture commercial products for general sale or for use in the manufacture of products intended for general sale is prohibited. Transfer of the cells to anyone not employed within the same organization, whether for financial benefit or not, is prohibited. If you are unwilling to accept the terms of this LIMITED USE LICENSE, do not ORDER or use them, and immediately return the cells for credit. Violators of this Limited Use License will be prosecuted to the fullest extent of the law.
HepaRG is a trademark of BioPredic International company
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d'importation et d'exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L'acheteur (c'est-à-dire l'utilisateur final) est tenu d'obtenir une autorisation d'importation auprès du Ministère français de la Recherche, mentionné à l'article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l'autorisation d'importation requise.
Supplément
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Repr. 1A
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems-hepatocytes derived from induced pluripotent stem cells, HepaRG
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Journal of applied toxicology : JAT, 37(3), 382-390 (2016-08-03)
The approach for predicting the degree of drug-induced liver injury (DILI) risk was investigated quantitatively in a modified multiparametric assay using HepaRG cells. Thirty-eight drugs were classified by DILI risk into five categories based on drug labels approved by the
Articles
Oral drug delivery involves dissolution in the small intestine and absorption across the enterocyte barrier into the portal vein followed by subsequent delivery through the liver into the systemic circulation.
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