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H0541

Sigma-Aldrich

Anti-HOXB7 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-HHO.C1, Anti-HOX2, Anti-HOX2C, Anti-Hox-2.3

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~24 kDa

Espèces réactives

human

Concentration

~1.0 mg/mL

Technique(s)

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXB7
indirect immunofluorescence: 1-2 μg/mL using using paraformaldehyde fixed HEK-293T cells over expressing human HOXB7
western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXB7

Numéro d'accès UniProt

P09629

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HOXB7(3217)
mouse ... Hoxb7(15415)

Description générale

Homeobox B7 (HOXB7) gene is mapped to human chromosome 17q21.32. In vertebrates, 39 HOX genes are organized into four clusters (HOXA-HOXD), located on different chromosomes (7p15, 17q21.2, 12q13, and 2q31). HOX proteins have a highly conserved 60-amino-acid region (the homeobox).

Spécificité

Anti-HOXB7 (C-terminal) recognizes human HOXB7 (also known as HOX2; HOX2C; HHO.

Application

Anti-HOXB7 (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Actions biochimiques/physiologiques

The homeobox with DNA-binding activity, contributes to their activity as transcription factors. Hox genes are evolutionarily conserved transcription factors, which act to control important development pathways involved in the morphogenesis of the embryo. HOXB7 is expressed in various human hematopoietic cell lines and tissues as well as in proliferating melanocytes. In addition to roles in normal development, altered homeobox gene function or expression is implicated in carcinomas associated with breast, prostate, kidney, colon, skin and brain.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
049K4829

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Dong Gao et al.
American journal of physiology. Cell physiology, 315(5), C675-C686 (2018-08-02)
Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with nonmelanoma skin cancer. The involvement of homeobox B7 ( HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7
Elisabetta Manuela Foppiani et al.
Stem cell research & therapy, 10(1), 101-101 (2019-03-21)
The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing
M T Lewis
Breast cancer research : BCR, 2(3), 158-169 (2001-03-16)
Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic
Yang Yang et al.
Molecular medicine reports, 16(3), 2773-2778 (2017-07-06)
Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. Unfortunately, treatment failures are common due to metastasis and chemore-sistance, however, the underlying molecular mechanism remains unclear. Accumulating evidence indicated that the homeobox B7 (HOXB7) gene was
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification

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