GW21310
Anti-RGS7 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-Regulator of G-protein signaling 7
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About This Item
Code UNSPSC :
12352203
Source biologique
chicken
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
rat, mouse, human
Fabricant/nom de marque
Genway 15-288-21310
Technique(s)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... RGS7(6000)
Description générale
RGS7 (regulator of G-protein signaling 7) is a member of the R7 subfamily of RGS superfamily of regulators, and shares high homology with RGS9-2. It is composed of the catalytic RGS domain, a dishevelled, EGL-10 and pleckstrin (DEP) domain in its N-terminal, along with a G protein γ subunit-like (GGL) domain. It is both a soluble cytosolic protein as well as a membrane protein.
Immunogène
Immunogen Sequence: GI # 11140809, sequence 227-262
Recombinant regulator of G-protein signalling 7
Application
Anti-RGS7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Actions biochimiques/physiologiques
Regulator of G-protein signaling 7 belongs to a subfamily of regulator of G protein signaling (RGS) proteins, which modulate G protein signaling by acting as GTPase-activating proteins for G protein α-subunits. RGS7 exists as a dimer with the G protein β(5)-subunit. It plays a major role in the pathogenesis of panic disorder (PD). RGS7 has a potential role in neurons communicating between classical heterotrimeric G protein subunits and/or their effectors at the plasma membrane and the cell nucleus. It helps in regulating signaling by μ-opioid receptor (MOR) and dopamine D2 receptor (D2R) and are implicated in drug addiction, movement disorders and nociception.
Forme physique
Solution in phosphate buffered saline containing 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Ikuo Masuho et al.
The Journal of biological chemistry, 288(35), 25129-25142 (2013-07-17)
Regulator of G protein signaling (RGS) proteins play essential roles in the regulation of signaling via G protein-coupled receptors (GPCRs). With hundreds of GPCRs and dozens of G proteins, it is important to understand how RGS regulates selective GPCR-G protein
J H Zhang et al.
The Journal of biological chemistry, 276(13), 10284-10289 (2001-01-21)
The role that Gbeta(5) regulator of G protein signaling (RGS) complexes play in signal transduction in brain remains unknown. The subcellular localization of Gbeta(5) and RGS7 was examined in rat PC12 pheochromocytoma cells and mouse brain. Both nuclear and cytosolic
Satoshi Takida et al.
Molecular pharmacology, 67(1), 132-139 (2004-10-22)
Regulator of G protein signaling (RGS) proteins modulate G protein signaling by acting as GTPase-activating proteins for G protein alpha-subunits. RGS7 belongs to a subfamily of RGS proteins that exist as dimers with the G protein beta(5)-subunit. In this report
Christa Hohoff et al.
Journal of neural transmission (Vienna, Austria : 1996), 116(11), 1523-1528 (2008-09-03)
Following our recent finding of Rgs2 playing a role in the development of human panic disorder (PD), we examine another positional and functional candidate from the functionally interwoven Rgs (regulator of G-protein signaling) family, Rgs7, in the pathogenesis of PD.
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