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EPS002

Sigma-Aldrich

MS-275

A HDAC1 and HDAC3 inhibitor

Synonyme(s) :

MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

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About This Item

Formule empirique (notation de Hill):
C21H20N4O3
Numéro CAS:
209783-80-2
Poids moléculaire :
376.41
Numéro MDL:
MFCD03453552
Code UNSPSC :
12352200
ID de substance PubChem :
329799578
Nomenclature NACRES :
NA.41

Pureté

≥99%

Solubilité

DMSO: 38 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

Clé InChI

INVTYAOGFAGBOE-UHFFFAOYSA-N

Informations sur le gène

human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)

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Description générale

Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM).

Application

MS-275 has been used as a histone deacetylase-1 inhibitor.

Actions biochimiques/physiologiques

HDAC inhibitor; antiproliferative.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H360

Classification des risques

Acute Tox. 3 Oral - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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