E1151

Anti-ERAB antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-Endoplasmic Reticulum-Associated Amyloid β-Peptide-Binding Protein
• Numéro MDL: MFCD02096320
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 27 kDa
• Espèces réactives: human
• Conditionnement: antibody small pack of 25 μg
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using human cerebellum tissue; western blot: 1-3 μg/mL using human SK-N-SH cells
• Numéro d'accès UniProt: Q99714
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Informations sur le gène: human ... HSD17B10(3028)

Description

Description générale

The gene HSD17B10 (hydroxysteroid (17-β) dehydrogenase 10) encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.

Spécificité

By immunoblotting, the antibody detects native human ERAB. It does not react with mouse or rat.

Immunogène

synthetic peptide corresponding to amino acids 100-116 of human ERAB protein.

Application

Anti-ERAB antibody produced in rabbit is suitable for immunohistochemistry at a working concentration of 1-2μg/mL using human cerebellum tissue with DAB detection and for immunoblotting at 1-3μg/mL using human neuroblastoma SK-N-SH cells with chemiluminescence detection.

Actions biochimiques/physiologiques

The gene product is a subunit of mitochondrial ribonuclease P and plays a pivotal role in in mitochondrial tRNA maturation. It catalyzes the oxidation of a wide variety of fatty acids and steroids. The gene is linked to the neuronal dysfunction associated with Alzheimer disease (AD).

Forme physique

Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves