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D5318

Sigma-Aldrich

DCP-LA

≥95% (HPLC), oil

Synonyme(s) :

2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924

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About This Item

Formule empirique (notation de Hill):
C20H36O2
Numéro CAS:
28399-31-7
Poids moléculaire :
308.50
Numéro MDL:
MFCD09265251
Code UNSPSC :
12352200
ID de substance PubChem :
24724463
Nomenclature NACRES :
NA.77

Pureté

≥95% (HPLC)

Forme

oil

Couleur

clear

Solubilité

DMSO: >2 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CCCCCC1CC1CC2CC2CCCCCCCC(O)=O

InChI

1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22)

Clé InChI

CONYTTFKIUJZOF-UHFFFAOYSA-N

Actions biochimiques/physiologiques

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

Caractéristiques et avantages

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Takahiro Yaguchi et al.
Neuroreport, 17(1), 105-108 (2005-12-20)
In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the
Takeshi Kanno et al.
Journal of lipid research, 47(6), 1146-1156 (2006-03-08)
This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance liquid chromatography, DCP-LA
Joshua H K Tam et al.
PloS one, 11(10), e0161445-e0161445 (2016-10-25)
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is
Ling-Yu Qiu et al.
Molecular medicine reports, 16(3), 2953-2961 (2017-07-06)
Anion exchanger 3 (AE3) is known to serve crucial roles in maintaining intracellular chloride homeostasis by facilitating the reversible electroneutral exchange of Cl‑ for HCO3‑ across the plasma membrane. Our previous studies reported that sasanquasaponin (SQS) can inhibit hypoxia/reoxygenation (H/R)‑induced

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