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C9415

Sigma-Aldrich

Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Nε-Boc-Lys methyl ester

≥85% (HPLC)

Synonyme(s) :

CGP-29287

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About This Item

Formule empirique (notation de Hill):
C72H110N20O15
Numéro CAS:
93287-54-8
Poids moléculaire :
1495.77
Numéro MDL:
MFCD00133577
Code UNSPSC :
12352200
ID de substance PubChem :
329775207

Pureté

≥85% (HPLC)

Forme

solid

Technique(s)

ligand binding assay: suitable

Température de stockage

−20°C

Chaîne SMILES 

CC[C@H](C)[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc4ccccc4)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC

InChI

1S/C72H110N20O15/c1-9-44(4)59(65(100)89-55(36-48-39-78-42-83-48)62(97)85-51(67(102)105-8)25-16-17-29-81-70(103)107-72(5,6)7)91-58(94)37-57(93)52(33-43(2)3)86-63(98)54(35-47-38-77-41-82-47)87-61(96)53(34-45-21-12-10-13-22-45)88-64(99)56-28-20-32-92(56)66(101)50(27-19-31-80-69(75)76)84-60(95)49(26-18-30-79-68(73)74)90-71(104)106-40-46-23-14-11-15-24-46/h10-15,21-24,38-39,41-44,49-57,59,93H,9,16-20,25-37,40H2,1-8H3,(H,77,82)(H,78,83)(H,81,103)(H,84,95)(H,85,97)(H,86,98)(H,87,96)(H,88,99)(H,89,100)(H,90,104)(H,91,94)(H4,73,74,79)(H4,75,76,80)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-/m0/s1

Clé InChI

DLAHCJHYEAZDLE-VRYQDWSQSA-N

Actions biochimiques/physiologiques

Primate-specific renin inhibitor with prolonged duration of action.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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J Nussberger et al.
Life sciences, 42(17), 1683-1688 (1988-01-01)
To prevent in vitro generation of angiotensins, the renin inhibitor CGP 29287 (CGP) was added to blood sampling tubes. Plasma immunoreactive angiotensin (ir-ANG) I and II were simultaneously measured by radioimmunoassay after rapid and quantitative extraction from a single plasma
M M de Gasparo et al.
Hypertension (Dallas, Tex. : 1979), 11(3), 209-216 (1988-03-01)
The mechanism by which monoclonal antibodies directed against human renin (R3-36-16 and R3-47-10) inhibit renin activity was investigated using various substrates. Both antibodies acted as potent inhibitors of human renin activity when human angiotensinogen was used as a substrate. However
J M Wood et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 7(2), S37-S42 (1989-04-01)
We have developed marmoset models for the in vivo evaluation of primate-specific inhibitors of human renin. After acute intravenous administration to normotensive sodium-depleted marmosets, renin inhibitors of different structural types induced a maximum hypotensive response of a magnitude similar to
J M Wood et al.
Journal of cardiovascular pharmacology, 10 Suppl 7, S96-S98 (1987-01-01)
In this study, the hypotensive efficacy of a renin inhibitor was investigated during chronic administration. The renin inhibitor CGP 29,287 was administered by continuous intraperitoneal infusion with osmotic mini-pumps to normotensive marmosets fed a low-sodium diet. Marmosets received a dose
J M Wood et al.
Clinical and experimental hypertension. Part A, Theory and practice, 9(2-3), 337-343 (1987-01-01)
The primate-specific renin inhibitor CGP 29287 (30 mg/kg/d, n = 5) or the converting-enzyme inhibitor CGS 14831 (30 mg/kg/d, n = 8) were administered by continuous intraperitoneal infusion via osmotic minipumps to normotensive marmosets fed a low salt diet. CGP
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