C2854

Caspase 2 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein

• Synonyme(s) : Ich-1, Nedd2
• Numéro MDL: MFCD02686998
• Code UNSPSC : 12352200

Propriétés

• Produit recombinant: expressed in E. coli
• Pureté: ≥95% (SDS-PAGE)
• Forme: buffered aqueous solution
• Activité spécifique: >1000 units/mg protein
• Poids mol.: inactive proenzyme 56 kDa (active form consists of 17 kDa and 10 kDa subunits); ≥30 kDa
• Numéro d'accès UniProt: P42575
• Température de stockage: −20°C
• Informations sur le gène: human ... CASP2(835)

Description

Actions biochimiques/physiologiques

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.

Définition de l'unité

One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.

Forme physique

Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable